The Mancunian Way will be closed this weekend so that scheduled maintenance work can be carried out.
The closure, which takes place annually, will allow essential work to take place to keep the bridge safe for road users.
The work will include safety inspections, road repairs, lighting inspections, street sweeping drainage and general work to improve any defects.
Given the accidents which have taken place on the road in recent months it is essential that these works can take place to ensure the continued safety of motorists.
The closure will be in place from 5am on Saturday, 12 March until 7pm on Sunday, 13 March.
Signed diversions will be in place for the duration of the closure.